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RabbitMQ is a message-broker software that routes messages between services. In the context of Python, RabbitMQ is often used for microservices architectures due to its robustness and reliability, allowing for effective communication between different parts of an application. Python developers using RabbitMQ are able to create highly scalable, distributed, and decoupled applications. To excel in Python jobs requiring RabbitMQ proficiency, a deep understanding of asynchronous messaging principles and hands-on experience with the RabbitMQ Python library, Pika, is often essential.